Investigation of the effects of different doses of sugammadex on kidney histopathology in rabbits with acute renal failure

Abstract

Objective: In our study, we hypothesised that using high doses, ie. 16 mg / kg sugammadex during general anesthesia after acute renal failure in rabbits would lead to a deteriorated renal histopathology due to the accumulation of rocuroniumsugammadex complex in the tubules. We aimed to investigate the effect of different doses of sugammadex (4 or 16 mg) on experimental kidney histopathology in rabbits with acute renal failure.

Methodology: Eight New Zealand white adult male rabbits were used in the study. The rabbits were divided into 2 groups of four. The first group received low dose (4 mg) sugammadex and the second group received high dose (16 mg) sugammadex. Rabbits were administered 20 mg / kg of cisplatin intravenously 4 hours before general anesthesia and an acute renal failure model was established. After general anesthesia was applied, V-GEL® Rabbıt was placed to all experimental animals to provide airway safety. All animals were manually ventilated using an anesthesia device. At the 25th min after induction, the rabbits in Group D received 4 mg / kg sugammadex iv, and the those in Group Y received 16 mg / kg sugammadex iv. At the end of the experiment, all experimental animals were sacrificed, and the kidneys were removed, and histopathologic examination was performed.

Results: At the end of our study all experimental animals were sacrificed. There was no statistically significant difference between findings in the kidneys of animals of Group Y and Group D on histopathologic evaluation.

Conclusion: The results of our study did not reveal any differences between the renal histopathological appearances of rabbits receiving 4 mg / kg or 16 mg /kg sugammadex IV.