ORIGINAL ARTICLE – Safety of Tramadol as a Pre-Induction Agent

  • Dr Tariq *Consultant Anesthesiologist & Pain Management Specialist, KRL General Hospital, Islamabad (Pakistan).
Keywords: Pre-induction, Tramadol, Safety, Seizure activity.

Abstract

Objective: To study the safety profile of intravenous use of tramadol immediately before induction of general anesthesia.

Design: Prospective, observational study.

Study Period: January 2005 to October 2007.

Setting: Combined MilitaryHospitalMultan, MilitaryHospitalRawalpindi and RailwayHospitalRawalpindi.

Patients & Methods: 600 patients of ASA-I to ASA-III, aged 10-50 years, undergoing elective surgery were selected for the study under convenient sampling. Children less than 10 years were excluded. Morbidly obese and patients with history of syncope, convulsive syncope, panic attacks and other convulsive events were excluded. Ladies undergoing caesarian section were also excluded from the study. The patients were injected 1.5mg/kg body weight, but not exceeding 100mg of tramadol (100mg of the drug diluted to 10 ml) intravenously, slowly over a period of two minutes as a part of pre-induction regimen. Patients were monitored for any untoward signs and symptoms for 10 min and all observations were recorded.

Results: The main complications / side-effects observed were nausea / vomiting, sweating, heart sinking and seizures in that order. Out of 600 patients, 47 (7.83 %) patients complained of nausea alone and 9(1.5%) patients had a bout of vomiting, 23 (3.88%) patients were observed to have sweating, 31 (5.17%) female patients complained of heart sinking and 2(0.33%) patients had had seizure activity.

Conclusion: We conclude that although the use of IV tramadol as a pre-induction agent is associated with a low risk of side effects, but due to its potential to cause seizure activity, it is best avoided in the environments where adequate resuscitative measures are not ava

Citation: Khan TH. Safety of tramadol as a pre-induction agent. Anaesth Pain & Intensive Care 2009;13(2):57-60.

Published
06-27-2019
How to Cite
Tariq, D. (2019). ORIGINAL ARTICLE – Safety of Tramadol as a Pre-Induction Agent. Anaesthesia, Pain & Intensive Care. Retrieved from https://mail.apicareonline.com/index.php/APIC/article/view/960
Section
Original Articles