The effect of dexmedetomidine on myocardial ischemia reperfusion injury in streptozotocin induced diabetic rats

  • Mustafa Arslan Department of Anaesthesiology and Reanimation
  • Fatih Poyraz Department of Cardiology
  • Hasan Ali Kiraz Department of Anaesthesiology and Reanimation, Medical Faculty, Onsekiz Mart University, Canakkale, (Turkey)
  • Metin Alkan Department of Anaesthesiology and Reanimation
  • Gülay Kip Department of Paediatric Dentistry
  • Özlem Erdem Department of Pathology; 6Department of Cardiovascular Surgery
  • Abdullah Özer Department of Cardiovascular Surgery
  • Volkan Sivgin Department of Anaesthesiology and Reanimation
  • Faruk Metin Comu Department of Physiology Medical Faculty, Kirikkale University, Afyonkarahisar, (Turkey)
Keywords: Ischemia reperfusion, Dexmedetomidine, Myonecrosis, İnflammatory cell infiltration, Diabetic rat

Abstract

Objective:

Ischemia/reperfusion (I/R) injury is an important cause of myocardial damage by means of oxidative, inflammatory, and apoptotic mechanisms. The aim of the present study was to examine the potential cardio-protective effects of dexmedetomidine in a diabetic rat model of myocardial I/R injury.

Published
01-25-2019
Issue
Vol.19 No.4(2015): October-December
Section
Original Articles