Amphotericin B induced hypokalemia in a diabetic patient with rhino-orbitocerebral mucormycosis

  • Rajeev Sharma Department of Anesthesiology, Lady Hardinge Medical College & Associated Hospitals, New Delhi, (India)
  • Sushmita Bairagi Department of Anesthesiology, Lady Hardinge Medical College & Associated Hospitals, New Delhi, (India)
  • Sashmita Das Department of Anesthesiology, Lady Hardinge Medical College & Associated Hospitals, New Delhi, (India)
  • Jyotika Kumar Department of Anesthesiology, Lady Hardinge Medical College & Associated Hospitals, New Delhi, (India)

Abstract

Rhino-orbito-cerebral mucormycosis is an aggressive and potentially lethal invasive fungal infection. Surgical debridement and amphotericin B remain the mainstay of treatment, however, associated side effects of amphotericin B like nephrotoxicity, hypokalemia, hypertension and arrhythmias need to be addressed. We discuss the anesthetic management of a 47 year old male with uncontrolled diabetes diagnosed with left sinoorbital mucormycosis posted for surgical debridement. The patient received amphotericin B and insulin preoperatively. Nephrotoxicity due to amphotericin B led to hypokalemia in this patient. We also discuss the role of liposomal formulation in preventing hypokalemia and other side effects associated with use of amphotericin.

 

Published
01-20-2019
How to Cite
Sharma, R., Bairagi, S., Das, S., & Kumar, J. (2019). Amphotericin B induced hypokalemia in a diabetic patient with rhino-orbitocerebral mucormycosis. Anaesthesia, Pain & Intensive Care, 90-93. Retrieved from https://mail.apicareonline.com/index.php/APIC/article/view/144
Section
Case Reports