Correspondence: Dr. Poonam S. Ghodki, Department of Anesthesiology, Shrimati Kashibai Navale Medical College and General Hospital, Pune, Maharashtra, (India); E-mail: drpoonamghodki@gmail.com
ABSTRACT
Obstetric hemorrhage, a preventable condition, is one of the leading causes of death in developing countries. The role of anesthesiologist in the management of obstetric hemorrhage is very critical. The crux of management of obstetric hemorrhage is a consensual planning with formation of a multidisciplinary team and formulating a logistic protocol that can be disseminated locally for managing catastrophes. This review highlights the optimum preoperative care to assess the risk factors and isolate the patients prone to develop peripartum hemorrhage and also deals with the most recent guidelines and management protocols including conservative and interventional modes of treatment. Details of anticipated and unanticipated obstetric hemorrhage, fluid and blood transfusion strategies are discussed.
Key words: Hemorrhage, antepartum; Hemorrhage, intrapartum; Hemorrhage, postpartum; Obstetric hemorrhage; Multidisciplinary team; Blood transfusion.
Citation: Ghodki PS, Sardesai SP. Obstetric hemorrhage: anesthetic implications and management. Anaesth Pain & Intensive Care 2014;18(4):405-414
INTRODUCTION
Obstetric hemorrhage is one of the leading causes of maternal mortality in developing countries.1,2 Even in developed countries, it is a complication for which highest rate of substandard care and potential avoidance is observed.3 A study by World Health Organization (WHO) revealed that 25-30% of maternal deaths are due to peripartum hemorrhage globally.4 Advances in obstetrics including improvement in evaluation methods and introduction of non interventional radiological techniques of management have progressively decreased maternal morbidity and mortality.5,6 Unfortunately, few parturients sustain profound peripartum hemorrhage that overwhelms the compensatory mechanisms leading to poor outcomes.
Applying conventional definition of hemorrhage to peripartum hemorrhage may be misleading as blood loss up to 1000 ml is not uncommon during deliveries.7 Although no consensus exists on the definition of massive obstetric hemorrhage, presence of either of the following has been described:8
The clinical utility of these definitions cannot be validated in routine practice and the intervention and management should be tailored to individual patients.
Obstetric hemorrhage is challenging to anesthesia providers as it is usually sudden in onset, rapid and maybe life threatening.9 A multidisciplinary approach with a team consisting of obstetrician, anesthesiologist, neonatologist and hematologist is imperative for management of peripartum bleeding.
In the context of obstetric hemorrhage, it is important to know;
One of the major reasons behind high mortality after peripartum hemorrhage is the failure to recognize the presence of bleeding.10 This happens because of the following reasons:
a. Inability to recognize the risk factors
This occurs due to inappropriate clinical evaluation and inadequate investigation of the expectant mother. A high degree of suspicion is hence needed to identify the risk factors responsible for hemorrhage in the antenatal period.11 Most of the antepartum hemorrhages can be diagnosed by ultrasonography (USG) in the antenatal check up, which can be repeated at frequent intervals in case of suspicion.5 USG not only helps in confirming the cause of hemorrhage but may also diagnose the presence of concealed hemorrhage in an otherwise asymptomatic patient.
b. Difficulty in exact blood loss estimation
Blood loss estimation becomes difficult in peripartum hemorrhage due to dilution by amniotic fluid or the loss may not be revealed in cases of intrauterine bleeding, bleeding in peritoneal cavity or in retroperitoneal hemorrhages.12,13 Hence a high clinical experience is needed for estimating the blood loss; else inadequate volume replacement is inevitable.
c. Difficulty in early diagnosis
Early signs of shock like tachycardia and increased systemic vascular resistance are masked by the normal physiological changes of pregnancy.14 Hemodynamic collapse occurs only when almost 35-45% of circulating volume is lost.15 Thus there is a delay in intervention to control the bleeding.
d. High uteroplacental blood flow
The uteroplacental unit receives 12% of the cardiac output at term pregnancy i.e. 700 ml/min.7 Hence it forms a potential source of rapid bleeding, which if unabated may become life threatening.
Hemodynamic status should always be correlated to the blood loss and any discrepancy has to be communicated to the obstetrician without delay.
TYPES AND CAUSES OF OBSTETRIC HEMORRHAGEObstetric hemorrhage can be broadly classified as antepartum, intrapartum and postpartum hemorrhage.
It is defined as hemorrhage that occurs after 24 weeks of gestation to before delivery.7 Although the incidence of APH is high, fortunately only a fraction of patients experience life threatening hemorrhage. It complicates 0.51 to 2.33% of pregnancies. APH represents a greater threat to fetus than mother and fetal compromise may precede maternal complications. Hence fetal demise occurs in 20-35% of cases.7,16 The causes and risk factors are elaborated in Figure 1.
Abruptio placentae:
Abruptio placentae is defined as a complete or partial separation of placenta from decidua basalis before delivery.17 Most of the cases of abruptio placentae originate from maternal hypertension and pre eclampsia. It may be revealed by per vaginal (PV) bleeding or may be concealed behind placenta (picture 1). It is associated with a perinatal mortality of up to 60%. Fetal compromise is likely because of the loss of placental surface area for materno-fetal exchange of oxygen and nutrients.18
Figure 1: Causes and risk factors of APHObstetric management:
Definitive management for abruptio placenta is delivery of infant and placenta that in turn depends on weeks of gestation.19 Expectant management may be considered in preterm patients with no hemodynamic compromise and no concomitant coagulopathies. Abruptio placenta has to be expeditiously managed because of the inherent risk of disseminated intravascular coagulation (DIC) in pregnancy. (Figure 2) Concealed type has the highest incidence of underestimation of true blood loss and is the most common cause of coagulopathy.20
Figure 2: Abruptio placenta and DICPlacenta previa is defined as the abnormal implantation of placenta in the lower uterine segment. It is further classified depending on its extension towards cervical os as marginal, partial or complete placenta previa (Picture 2). The incidence is around 0.4-0.8%.16
There is increased susceptibility in patients with prior uterine handling as the placenta gets implanted to the scarred area in uterus.21,22 Classical presentation of placenta previa is painless vaginal bleeding that may be overlooked by patient or the attending obstetrician.7 Timely ultrasonographic evaluation plays a pivotal role in early diagnosis5. It should be envisaged that per vaginal examination may lead to life threatening hemorrhage in patients having placenta previa. Nevertheless when the ultrasound report is inconclusive, PV examination may be warranted. A double set up is recommended for such high risk cases wherein the PV examination is carried out in the operating room in presence of anesthesiologist and neonatologist with full preparation for general anesthesia.7 Patient’s parts are painted and draped in lithotomy position for examination by obstetrician and the anesthesiologist is ready for intubation in case need of cesarean section arises.7,16
Obstetric management:
The goal of management is to delay delivery until fetal maturity and is dictated by the amount of bleeding. Tocolytics like magnesium sulfate, beta blockers, nifedipine and ritodrine are used with varying success rates.
Anesthetic plan in APH
Best anesthetic plan for abruptio placenta is general anesthesia with endotracheal tube, even in hemodynamiclly stable patients. This is because of the high propensity of post partum hemorrhage in patients of abruptio placenta.17 Rapid sequence induction has to be done considering all pregnant patients to be full stomach. The choice of induction agent strongly depends on the hemodynamic stability of the patient. Ketamine is the agent of choice in patients presenting with shock. Etomidate is another good alternative. However, thiopentone and propofol have to be used cautiously because of their deleterious effect on circulatory system. For maintenance, a volatile agent has to be added to prevent awareness with a concentration of not more than 0.5 MAC, else the chances of uterine atony and postpartum hemorrhage become high. Nitrous oxide should not be used for maintenance in case the indication for cesarean section is fetal distress. Pain has to be addressed well.23
Epidural analgesia can be offered to the patient as long as coagulation and volume status are acceptable.24
The type of anesthesia in placenta previa largely depends on hemodynamic stability of patient. Bonnar and colleagues determined that most of the anesthesiologists preferred neuraxial anesthesia over general anethesia in both elective and emergency situations.25 Spinal or epidural anesthesia may be considered in stable patients provided the possibility of placenta accreta has been ruled out.24 General anesthesia is administered in unstable patients with the above mentioned principles.26
INTRAPARTUM HEMORRHAGE (IPH)
It occurs in 1 in 2000 deliveries. The most common causes are abnormal placentation and uterine rupture. The risk factors for each are depicted in Figure 3.
Figure 3: Causes and risk factors of IPHIt is defined as abnormal attachment of placenta to uterine wall.27 Depending on the degree of myometrial invasion it is further classified as placenta accreta, increta and percreta (Picture 3).
Obstetric management:
Antenatal USG confirms diagnosis and allows preparation for delivery.28Once the diagnosis is confirmed, following protocol has to be followed-
Although rare, uterine rupture is the most life threatening emergencies in obstetrics; associated with high maternal and perinatal morbidity and mortality.36 It can either present in the form of scar dehiscence or complete uterine wall rupture.37
Obstetric management:
Fetal delivery with repair of ruptured uterine wall is the definitive treatment. Uterine and internal iliac arterial ligation may be done in anticipated cases.38-40 In intractable blood loss, as a last resort, obstetric hysterectomy is advocated without wasting time in decision making.41,42
POSTPARTUM HEMORRHAGE (PPH)
WHO has defined PPH as blood loss of >500 ml in first 24 hours or a 10% decline in hemoglobin from admission to post partum period. PPH occurs in around 10% deliveries.43 It can be either:Atonic uterus is responsible for 80% of PPH. It is defined as lack of efficient uterine contractility after placental separation.45,46
Early contemplation and administration of uterotonics (fig 4) is of paramount importance to prevent atony of uterus.
Table 1: Uterotonic drugs
Drug |
Description |
OXYTOCIN47,48 |
|
ERGOMETRINE49 |
|
PROSTAGLANDIN F2α AGONIST50,51 (Carboprost) |
|
PROSTAGLANDIN E1 ANALOGUE52(Misoprostol) |
|
If uterotonic drugs fail to contract the uterus following invasive measures are considered-
1. Bimanual compression of uterus.7,Obstetric trauma may occur during operative delivery for e.g. during cesarean section or episiotomy.44
Management depends on the type of hematoma. Small pelvic hematoma generally has no hemodynamic compromise and can be managed conservatively. In case of large hematoma, however, surgical exploration followed by evacuation may be demanded. In severe cases, vessel ligations may be warranted.45Optimal care has to be taken to prevent infection and septicemia. When uterine inversion is the precipitating factor for trauma, immediate replacement of uterus even prior to removal of placenta is considered as best management. This remedy requires general anesthesia with good relaxation aided by volatile agents.16,46
Coagulopathy:Other than obstetric causes of coagulopathy in pregnancy (abruption placenta, pre eclampsia), bleeding disorders should also be kept in mind as an important differential diagnosis.7 PPH may be the first indication in patients suffering from von Willebrand disease that is characterized by deficiency of vWF (von Willebrand factor).57A patient with menorrhagia when screened in antenatal clinic may be timely diagnosed for such types of bleeding diathesis.
Treatment includes administration of tranexamic acid, DDAVP (desmopressin), when refractory; the coagulation factor needs to be specifically replaced. In a patient diagnosed as vWD, epidural anesthesia may be safely performed if vWF > 50 IU/dl. 16,57
Other causes of PPH like retained placenta and products of conception require manual removal under general anesthesia with inhalational agents. These procedures are quite painful and hence adequate analgesia should be provided.
THE ROLE OF ANESTHESIOLOGIST
The anesthesiologists have thorough knowledge of normal physiological changes in pregnancy and hence their role is crucial in the management of obstetric hemorrhage. Multiple tasks have to be carried out quickly and with expertise in the event of massive hemorrhage.58 Hence timely and effective communication between the obstetrician and anesthesiologist is adjuratory.
Pre anesthetic evaluation:
The involvement of anesthesiologist from before the delivery of patient is fundamental. One needs to proficiently recognize the patients with risk factors (vide supra) and isolate and prepare them accordingly. Investigations requiring special attention are hemoglobin levels, coagulation studies, blood grouping and cross matching.6 Availability of whole blood and blood products have to be confirmed before institution of anesthesia in identified patients. Prevalence of chronic anemia being a concern in developing countries, it has to be separately dealt with and treated with oral or parenteral iron.59Recombinant human erythropoietin may be required in refractory cases.60 Coagulaopathies (thrombocytopenia, coagulation factor deficiencies) can be diagnosed by doing a thromboelastogram (TEG) preoperatively.61TEG is also helpful in patients who are on low molecular weight heparin and to guide safety for central neuraxial blockade. It is pertinent for the anesthesiologist to go through the USG reports for any missed out findings.
Assessment of intravascular depletion:
The extent of bleeding is almost always underestimated in obstetric patients.62Signs suggestive of hypovolemia in APH patients should be monitored carefully:62,63
Irrespective of the degree of hypovolemic shock, fluid therapy is best guided by continual assessment of maternal vital signs, urine output, hemoglobin and acid base balance.62-64
Interventional radiology suite:
With the advances in treatment modalities, placement of arterial catheters and occlusion balloons before delivery is currently the choice whenever major hemorrhage is suspected.65This is a well recognized and less radical approach that avoids peripartum hysterectomy and preserves fertility. In contemplated cases, indwelling epidural catheters may prove beneficial.66,67In advanced centers where facility for shifting the patient from operating room to radiology suite is available, the patient may be transferred by attending anesthesiologist once hemodynamically stable.67In the interventional radiology suite, embolisaiotn is performed under fluoroscopic guidance. Occasionally, angiographic occlusion balloon catheters (in hypogastric/common iliac arteries) may be needed.
Intraoperative role:
Care for an actively bleeding mother should follow an algorithm that has rapid and successive sequences of medical and surgical approaches to stem bleeding. It is vital that junior anesthesiologists and obstetricians do not perceive the calling of senior colleagues as involving ‘loss of face’. At the same time, senior staff must be in receptive mode to concerns expressed by their juniors. Hence, CALL FOR HELP, as apt communication is the major pillar in the management of obstetric hemorrhage.58,68
Resuscitation:
The urgency and measures taken to resuscitate and arrest hemorrhage need to be tailored to the degree of shock.68,69
Maternal resuscitation:68,70(Adapted and modified from RCOG Green top guidelines no. 52, 2009)
Minor bleeding (Up to 100-1000 ml blood loss, no s/o clinical shock)
In massive hemorrhage (> 1000ml/ continuing blood loss, or patient in clinical shock) mothers need active resuscitation. Following factors need to be addressed;
Clinical signs of shock have to be continuously monitored like color of the patient, pallor, urine output, temperature and capillary refill time. Invasive blood pressure monitoring may be done for fragile patients.68,69All the parameters recorded have to be documented well on a flow chart for further references.
Fluid and blood replacement therapy:The cornerstones of resuscitation in peripartum hemorrhage are restoration of both blood volume and oxygen carrying capacity.68-70 All delivery units, especially small units without the blood bank facility, should maintain a supply of O Rh negative blood, as this might offer the only means of restoring oxygen carrying capacity within an acceptable timescale. In addition, the Confidential Enquiry into Maternal and Child Health recommends that women with known risk factors for obstetric hemorrhage should not be delivered in a hospital without a blood bank on site.68
The clinical picture is the main determinant for the need of blood transfusion and time should not be wasted for laboratory results. Volume replacement must be undertaken on the basis that blood loss is often grossly underestimated. Compatible blood in the form of red cell concentrate is the best fluid to replace major blood loss and should be transfused whenever deemed necessary.68,69
A 2006 guideline from the British Committee for Standards in Hematology summarizes the main therapeutic goal of management of massive blood loss is to maintain:68
There is controversy as to the appropriate fluids for volume resuscitation.70 The nature of fluid infused is of less importance than rapid administration and warming of the infusion.70,71
Table 2: Fluids for volume resuscitation
IV Fluid |
Use |
Crystalloid | Up to 2 lit of Hartmann’s solution |
Colloid | Up to 1-2 lit colloid until blood arrives |
Blood | CrossmatchedIf crossmatched blood unavailable, give uncrossmatched group-specific blood OR ‘O-negative’ blood |
Fresh frozen plasma (FFP) | 4 units for every 6 units of red cells or PT/APTT > 1.5 x mean control ( 12-15 ml/kg or total 1 lit) |
Platelet concentrates | If platelet < 50 x 10 9 |
Cryoprecipitate | If fibrinogen < 1 g/l |
In cases of massive hemorrhage (80% blood volume loss), large volume of fluid replacement fluids leads to clotting factors deficiency making patient prone to develop DIC.20 The challenge of replacing with blood components lies in the fact that in the event of active and ongoing bleeding, there is always going to be a short delay in arrival of laboratotry reports. Hence, in face of relentless bleeding empirical treatment with 1 liter of FFP and 10 units of cryoprecipitate (2 packs) can be given, while awaiting coagulation studies.72 Such empirical use of FFP and cryoprecipitate is in line with the recommendations in the British Committee for Standards in Hematology guideline.68 A replacement therapy guided by ROTEM may always be helpful in saving time.61
Subsequent management after blood transfusion:
The increasingly important issues in blood transfusion are adverse effects associated with transfusion, including potential infection and transmission of prions, rising costs and the possible future problems of availability.68 Patients should be monitored carefully for diagnosing the complications (fever, hyperkalemia, hypocalcemia, citrate toxicity etc) seen after massive blood transfusion. Equal attention should be given to rebound hypercoagulation and thromboembolism that follows blood transfusion especially in pregnancy which is a hypercoagulable state by itself.63 This can be prevented by usage of graduated compression stockings and pharmacological thromboprophylaxis.68,70
Intrauterine fetal resuscitation:
There is a constant threat to the fetus in obstetric hemorrhage as the uteroplacental circulation is at risk because of the following reasons-7,16
In pregnanacy, concerns have been raised regarding placental insufficiency, whether the woman will make up her hemoglobin before delivery and whether the collected units will be sufficient in the event of major obstetric hemorrhage.75 Hence, the use of pre-autologous blood deposit is not recommended in pregnancy (exception being a mother who is Jehovah’s witness)76.
Intra operative cell salvage:
This technique is commonly being used in cardiac, orthopedic and vascular surgeries with relative reduction of blood transfusion by 39%.77 The use of cell salvage in peripartum hemorrhage is still controversial. The potential difficulty in bleeding mothers is the effective removal of amniotic fluid and degree of contamination with fetal red cells. Still, several bodies based on current evidence have endorsed cell salvage in obstetrics. Intraoperative cell salvage has an undisputed role in patients who refuse blood or blood component transfusion (Jehovah’s Witness) and in patients where massive blood loss is anticipated (placenta accreta, percreta)77
Recombinant factor VIIa (rFVIIa) therapy:
rFVIIa was developed for patients with hemophilia and the first report of its use in peripartum hemorrhage was released in 2001.78 A 2007 review identified case reports of 65 mothers treated with rFVIIa, with controversial results as 30 out of 65 patients had to undergo peripartum hysterectomy. It is hence suggested that rFVIIa may be used as an adjuvant to standard pharmacological and surgical treatment under the guidance of a hematologist. The recommended dose is 90 mcg/kg, repeated within 15-30 minutes. Empirical use of rFVIIa is not advisable as it is not relevant to use this drug in low fibrinogen levels and in thrombocytopenia.78,79 The pre requisite for administration of rFVIIa is fibrinogen level> 1 g/l and platelet count > 20x109.
Use of antifibrinolytics:
Although evidence is conflicting, there is a consensus that antifibrinolytic agents (tranexamic acid) seldom, if ever, have a place in the management of obstetric hemorrhage.68
CONCLUSION
The role of anesthesiologist in the management of obstetric hemorrhage is crucial. It should be envisaged that the various guidelines available for management should be incorporated into a local protocol for each maternity unit. Above all, a multidisciplinary approach with consensual planning catalyses the management even in crisis situation.
REFERENCES [Free full text] [PubMed]